Pharmaceutical Organic Chemistry 2 Notes

 Unit 1  Benzene and its derivatives Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule Reactions of benzene – nitration, sulphonation, halogenationreactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation. Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic … Read more

 Unit 2  Phenol* – Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols Aromatic Amines* – Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts Aromatic Acids* – Acidity, effect of substituents on acidity and important reactions of benzoic acid. DOWNLOAD

 Unit 3  Fats and Oil Fatty acids – reactions. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils. Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination. DOWNLOAD

 Unit 4  Polynuclear hydrocarbons: Synthesis, reactions Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives DOWNLOAD

 Unit 5  Cyclo alkanes* Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only DOWNLOAD