Imperfect Pharmacy
3rd SEMESTER
PHYSICAL PHARMACEUTICS 1
UNIT 1
Solubility of drugs:
OPEN UNIT 1
UNIT 2
States of Matter and properties of matter:
State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solidcrystalline, amorphous & polymorphism.
Physicochemical properties of drug molecules:
Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications
OPEN UNIT 2
UNIT 3
Surface and interfacial phenomenon:
Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.
OPEN UNIT 3
UNIT 4
OPEN UNIT 4
UNIT 5
pH, buffers and Isotonic solutions:
Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.