Imperfect Pharmacy B. Pharmacy Notes 6th Semester
BIOPHARMACEUTICS & PHARMACOKINETICS
Unit 1
Introduction to Biopharmaceutics:
Absorption; Mechanisms of drug absorption through GIT, factors influencing drug
absorption though GIT, absorption of drug from non per-oral extra-vascular routes.
Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug
distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug
binding. Kinetics of protein binding, Clinical significance of protein binding of drugs.
OPEN UNIT 1
Unit 2
Elimination: Drug metabolism and basic understanding metabolic pathways renal
excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal
routes of drug excretion of drugs.
Bioavailability and Bioequivalence: Definition and Objectives of bioavailability,
absolute and relative bioavailability, measurement of bioavailability, in-vitro drug
dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to
enhance the dissolution rates and bioavailability of poorly soluble drugs.
OPEN UNIT 2
Unit 3
Pharmacokinetics: Definition and introduction to Pharmacokinetics, Compartment
models, Non compartment models, physiological models, One compartment open model.
Intravenous Injection (Bolus), Intravenous infusion and Extra vascular administrations.
Pharmacokinetics parameters – KE , t1/2,Vd, AUC, Ka, Clt and CLR- definitions, methods
of eliminations, understanding of their significance and application.
OPEN UNIT 3
Unit 4
Multicompartment models: Two compartment open model. IV bolus Kinetics of multiple
dosing, steady state drug levels, calculation of loading and maintenance doses and their
significance in clinical settings.
OPEN UNIT 4
Unit 5
Nonlinear Pharmacokinetics: Introduction, Factors causing Non-linearity. Michaelis-
Menten method of estimating parameters, Explanation with example of drugs.
